Chapters 1 to 6
Handbook of Basic Pharmacokinetics
·Chapter 1 is a list of terms used in the book.If you want to sound like an expert in pharmacokinetics all you have to do is learn these terms.Remember in science we require very precise definitions.Start learning these terms NOW.
·Chapter 2 -The LADMER system is a way of understanding what goes on in the body when any compound that has an effect on the body is administered or ingested.
See Figure 2-1 on page 17.
The LADMER System is key for us because it is the qualitative way of understanding drug action in a general way.See page 19.The second portion of this course will make our understanding quantitative.
Chapter 3 How the body is organized.
To understand how drugs work we first must understand how the body works.Chapter three is a very brief review of the basics of how the body is organized.Remember that form follows function.Therefore the anatomy of the body and its physiology and pathophysiology are linked.You must be able to link these things to be able to understand how the body is reacting to a drug.
Important tissues for this course are the epithelial because they represent the barrier for drug absorption and distribution.We will be dealing mostly with how a drug gets to the biophase and is eliminated not what it does.
Chapter 4 - The Cell Membranes are boundary surfaces that must be crossed by drugs to get to the biophase.
The nature of the cell membrane is discussed on page 28 & 29.
How is the cell membrane like a layer of surfactant??
What are the key factors that affect the permeability of the membrane?
What is the modified fluid mosaic model of the cell membrane?
What is the blood brain barrier?
How do sorption enhances work? (see pages 32 & 33)
Once a drug has managed to get to the Biophase what happens???
Chapter 5 This is the “R” in LADMER.It summarizes the key points covered in the first module in the pharmacotherapy sequence.(Not really but it does match up with what you will learn in much more detail in PHA 421)
Structural Specific Drugs
Enzyme-Linked & Channel-Linked Receptors
Drug Receptor Theories
Agonist
Antagonist
Etc.
Fick’s law describes absorption once the drug is in solution
q = -D A/h K (Co - Ci)
What are the anatomical and physiological factors that affect absorption?
Table 6-1 is a summary of the various ways that a drug might be absorbed.
Passive Absorption
Active Transport – Michaelis-Menten Equation
oConvective Absorption
Facilitated Transport
Ion Pair Transport
Endocytosis/Pinocytosis