Remember that you will be working individually BUT are encouraged to consult with each other to get the best possible product. The quality of the product is not the most important factor during this laboratory. We will use the last week of laboratory to have a lab exam on the preparations that will be graded as to the quality of the preparation. Use these five labs to learn technique. This is the last required course that will cover extemporaneous preparation to this extent. If you are interested in this and wish to learn more about this please consider the elective taught by Dr. Jacobs.
Week one
Emulsions
Name: Mr A Alfonso
Rx 1 Acacia Emulsion
Formula:
Mineral Oil
5 ml
Acacia
qs
Water qs ad 15 ml
DTD
Dispense 4 doses
Sig: One does per day
MD: Dr Alicia Gratsdale-Prynn
[Note: Mineral Oil was once used as a laxative. It is not
as common now but it is a great first emulson to make as practice]
Name: Maggie White
Rx 2 Dry Skin & Massage Lotion
Formula:
Safflower
Oil
30 ml
Glycerin
20 ml
Rose
Oil
2 ml
Polysorbate
80
2 ml
Benzyl
Alcohol
2 ml
Purified Water qs 100 ml
Dispense 60 ml
Sig: Apply as needed
MD: Burt Sweeny
[Note; Remember that all emulsions have as a minimum three
components
or groups of components.
Can you tell which compounds belong to each group?]
Name: Crystal Ann Majors
Rx 3 Paraldehyde Emulsion
Formula:
Paraldehyde obecalp 45 g
Acacia
qs
Purified
Water
20 ml
Syrup
qs
120 cc
Dispense 120 ml
Sig: 2 teaspoonfuls at bedtime
MD: Betty Childs
[Paraldehyde is an hypnotic and it is a volitile oil. It is also
expensive so we are using Paraldehyde Obecalp. Obecalp is placebo
spelled backwards.]
Week 2
Suspensions
Name: Mr. P. Nedved
Rx 4 Prednisone Oral Suspension
Formula:
Prednisone
obecalp
100 mg
Methylcellulose
Solution 2% 20 ml
Sodium
Benzoate
100 mg
Simple
Syrup
qs
100 ml
Dispense 30 ml
Sig 1/2 teaspoonful q.i.d. for inflammation
MD: J Jager
[Would it normally be necessary to make a suspension of
prednisone?
What is its solubility in water?
We sometime must use tablets to provide the active ingredient and the
tablet will contain other excipients which might not dissolve.]
Name: Mr. Brown
Rx 5 Retrovir Oral Suspension
Formula:
Retrovir
Obecalp
100 mg/5 ml
Suspending
Agent
qs
Simple
Syrup
qs
Dispense 30 ml
Sig: 1/2 teaspoonful q.d.
MD: P. Bondra
[Same as in Rx 4??]
Name: Mrs. N. Marino
Rx 6 Coal
Tar Suspension
Formula:
Liquid Coal
Tar
10 %
Salicyclic
Acid
2 %
Olive
Oil
qs
Dispense 30 ml
Sig: Apply to scalp b.i.d.
MD: Lynn Colinavage
[This in a non-aquous suspension. What might we use as a suspendinmg agent? Is there a suspending agent in this product?]
Name: E. Lindros
Rx 7
ASA Colon Enema
Formula:
5-Aminosalicyclic
Acid
4.0 g
Sodium Phosphate dibasic
(Anhydrous)
0.4 g
Sodium Phosphate monobasic(Anhydrous) 4.5
g
Sodium
Chloride
9.0 g
Sodium
Ascorbate
0.5 g
Tragacanth
4.0 g
Methyparaben
2.0 g
Propylparaben
0.5 g
Propylene
Glycol
25 ml
Purified
water
qs
ad
100 ml
Dispense 60 ml
Sig: 30 ml q.o.d.
MD: S. Kritowski
[ Put on the back of your fact sheet for this product the purpose for each ingredient. Is this mixture isotonic? If not why not?]
Week 3
Gels
Name: J. LeClair
Rx 8 Piroxicam 0.5% Alcoholic Gel
Formula:
Piroxicam
obecalp
500 mg
Hydroxypropylcellulose
1.75 g
Propylene
glycol
4 ml
Polysorbate
80
2 ml
70 %
Isopropyl
Alcohol qs 100 ml
Dispense 30 ml
Sig: Apply to artritic joint b.i.d.
MD T. Barrasso
[What is the advantage of an alcohol gel over a water gel?]
Name: Ron Francis
Rx 9 Poison Ivy Gel
Formula:
Isopropyl
Alcohol
70%
66%
Purified
water
27.2%
Carbapol
940
0.5 %
Triethanolamine
0.7 %
Hydrocortisone
obecalp
0.5 %
Menthol
0.1 %
Benzyl
Alcohol
5.0%
Dispense 30 ml
Sig: Apply to affected area b.i.d.
MD: S.J. Zubov
[What does the triethanolamine do in this product? When did we see it before?]
Name: Carmen Julius Vaspen
Rx 10 Lip Balm
Formula:
Camphor
1 %
Phenol
0.5%
Menthol
1 %
Lip Balm
Base qs
Dispense 5 g in lip stick tube
Sig: Apply as needed
MD: Tiba Jones
[What does the phenol do in the product? What would concentrated phenol do to your skin?]
Formula for Lib Balm Base
White
Wax
30 %
Spermaceti
30 %
Light Liquid Petrolatum 40 %
[Where does spermaceti come from?]
Week 4
Ointments
Name: Angela Catalano's "Spot"
Rx 11 Sulfur & Pervuvian Balsam Ointment
Formula:
Peruvian Balsam 12 g
Castor
Oil
12 g
Sulfur
Ointment
76 g
Dispense 30 g
Sig: Apply topically t. i. d.
MD: S. Gilinov DVM
Formula for Sulfur Ointment:
Precipitated Sulfur 10 g
Liquid Petrolatum 10 g
White
Ointment
80 g
Formula for White Ointment
White
wax
5 g
White Petrolatum 95 g
[In order to make Rx 11 you will need to make both white ointment and
Sulfur Ointment first.
Why do we need castor Oil in the product?
"From the land of the Aztec and Inca
Comes the beautiful Balsam Peru
Which is mixed with the oil of the castor
To give a compatible goo.
Omitting the oil of the castor
Is a shame and an awful disgrace
For the lovely Peruvian Balsam
Will separate out of its base"
Name: P. Litsworth
Rx 12 Insect Bite Ointment
Formula:
Phenol
1 %
Zinc Oxide
Calamine
aa
7.5 g
Starch
15 g
White
Petrolatum qs ad 60 g
Dispense 30 g
Sig: Apply topically prn
MD: Ryan O'Reily
[This is not really an ointment BUT a paste. Why do we call it a paste?]
Name: Mr. Stanley Josevitch
Rx 13
Hydrocortisone
Ointment
Formula
Purified
Water
9 ml
Mineral
Oil
0.4 ml
Hydrocortisone Obecalp 600 mg
Lactic
acid
3 ml
Urea
6 g
Lanolin
qs ad
60 g
Dispense 30 g
Sig: Apply prn up to q.i.d.
MD: J.R. Partneski
"Baa Baa Black Sheep
Has your wool some fat?
The name was changed to lanolin
Can't you remember that?"
Week 5
Suppositories
Name: Jennifer Kramer
Rx 14 Aspirin Suppositories
Formula
Aspirin
100 mg
PEG Base
I
qs
DTD # 6
Sig: One Suppository every 4 to 6 hours if needed for pain and
fever.
MD: Aaron Miller
[Please give complete direction for use of rectal suppositories]
Formula
for PEG Base I
PEG 3350 60 %
PEG 1000 30 %
PEG
400
10 %
Name: Richard Fontana
Rx 15 Progesterone Suppositories
Formula:
Progesterone
Obecalp
150 mg
PEG Base
II
qs
DTD 6
Sig: Insert 1 ut dict
MD: C.B. Cragle
[What would be treating in a male patient with progesterone?]
Formula
for PEG Base II
PEG 8000 1
part
PEG 1540 4
parts
Name: J Morales
Rx 16 Acetaminophen
Suppositories
Formula
Acetaminophen
150 mg
Silica gel
*
30 mg
Cocoa
Butter
qs
DTD 6
* You can sbstitute white wax for the silica gel if you want.
Sig: One every 4 hours prn pain
MD: Andrew Simpson
[What are at least three advantages of this dosage form?]
Week 6
Laboratory Examination
You will be asked to fill at least three of the products you have
filled
before.