Pharmaceutical Aerosols, Inhalations and Sprays
Pharmaceutical Aerosols are pressurized dosage forms containing one or more active ingredients which upon activation emit a fine dispersion of
liquid and/or solid materials in a gaseous medium.
This type of dosage form have some obvious advantages and some not so obvious advantages which can be just as important.
Aerosols are used to administer drugs to the lungs especially to treat respiratory conditions. They can also be used for topical application of drugs and for systemic action as the drug can be absorbed through the lungs into the blood supply.
Also the container acts to ensure that the drug cannot become contaminated and can protect a drug from moisture better than most packageing systems. Also the application of drugs topically can be done without the need to touch the skin. This i useful in painful burn situations (sunburn).
Can you name examples of an
aerosol product you have used ??
The aerosol has two principle ingredients. The active and the propellant. In the past we used freon as a common propellant in aerosols.
What environmental concern has reduced the use of freon as a propellant??
We have replaced halogenatedhydrocarbo propellants with hydrocarbon propellants like isobutane.
What are the advantages of using liquified propellant over compressed gas propellants such as CO2??
What are some of the disadvantages of isobutan like propellants??
What is Raults Law?? How does it apply to propellants??
Please read Chapter 13 pages 443 to 458.
This is the last topic to be covered for the final exam.
lets read ahead for thursday and discuss these dosge forms together!
How does a normal aerosol dispenser work?
How does a metered dose aerosol differ from a normal aerosol?
What is the difference between a two phase and three phase aerosol system?
How would you formulate an aerosol to produce a foam?
Inhalation
Inhalations are drugs or solutions of drug products adminitered by the nasal or oral respiratory route.
What are some examples of volatil drugs whose effect is by inhalation?
What is an atomizer? What is Bernoullis Principle? How does an atomizer work?
What is a nebulizer and how does it differ in use and mechanism from an atomizer?
What are vaporizers and humiderfiers and how do they differ?
Are WE Done???? Not really we have just begun.